Manuscript accepted by BMC Bioinformatics

During their respective Masters degrees, Richard Williams and Richard Greaves conducted some very elegant experiments using the ARTIMMUS simulation that elucidated the nature of regulation in EAE. Richard Williams’ work won the Best Immunological Modelling Paper award at ICARIS 2011, and it was his abstract that lead to the current journal submission. Richard W’s work was combined with work from Richard G, and yesterday the manuscript was accepted for publication in the BMC Bioinformatics journal. Winning a best paper prize and then being accepted for publication in this very respectable journal is a fantastic testament to the very high quality of work that these two have conducted (as Master’s students, no less)!

The paper reports three experiments, all excellent exemplars of how simulation facilitates work that could not be conducted in vivo. Manipulation of dendritic cell peptide presentation demonstrates that the regulation mediating recovery from autoimmunity in this model of EAE does not require regulatory T cells and their autoimmunity-inducing targets to be primed by the same dendritic cells. The paper reports that although CD4Th cells are invaluable in facilitating the cytotoxic T cell response, their physical presence and the temporal aspects of signals they deliver to dendritic cells modulate the magnitude of this response. Artificial means to deliver the signals that CD4Th cells are responsible for could yield more aggressive CTL responses that might overcome otherwise persisting disease.